| Date & Time | Game | Venue |
|---|---|---|
| December 13, 2021 | (3) Billerica Indians at (1) Shrewsbury Colonials | NorthStar Ice Sports |
| December 18, 2021 | (1) Shrewsbury Colonials at (6) Andover Golden Warriors | Breakaway Ice Center |
| December 22, 2021 | (4) Chelmsford Lions at (2) Shrewsbury Colonials | NorthStar Ice Sports |
| December 29, 2021 | (3) Shrewsbury Colonials at (6) Mansfield Hornets | Foxboro Sports Center |
| January 02, 2022 | (6) Shrewsbury Colonials at (5) Saint John's Shrewsbury Pioneers | New England Sports Center |
| January 05, 2022 | (1) Shrewsbury Colonials at (4) Central Catholic Raiders | Salem Ice Center |
| January 08, 2022 | (1) Shrewsbury Colonials at (2) Waltham Hawks | Veterans Memorial Rink |
| January 12, 2022 | (4) Shrewsbury Colonials at (2) Algonquin Titans | NorthStar Ice Sports |
| January 15, 2022 | (2) Westford Academy Ghosts at (4) Shrewsbury Colonials | NorthStar Ice Sports |
| January 19, 2022 | (1) Shrewsbury Colonials at (5) Billerica Indians | Chelmsford Forum |
| January 22, 2022 | (3) Andover Golden Warriors at (2) Shrewsbury Colonials | NorthStar Ice Sports |
| January 26, 2022 | (4) Shrewsbury Colonials at (2) Chelmsford Lions | Chelmsford Forum |
| January 28, 2022 | (5) Central Catholic Raiders at (2) Shrewsbury Colonials | NorthStar Ice Sports |
| February 02, 2022 | (1) Waltham Hawks at (3) Shrewsbury Colonials | NorthStar Ice Sports |
| February 05, 2022 | (3) Shrewsbury Colonials at (1) Wachusett Mountaineers | NorthStar Ice Sports |
| February 09, 2022 | (2) Shrewsbury Colonials at (0) Westford Academy Ghosts | Skate 3 |
| February 12, 2022 | (2) Mansfield Hornets at (3) Shrewsbury Colonials | NorthStar Ice Sports |
| February 17, 2022 | (2) Shrewsbury Colonials at (3) Pope Francis Cardinals | Olympia Center |
| February 20, 2022 | (2) Shrewsbury Colonials at (3) Newburyport Clippers
NEWBURYPORT BANK ICE HOCKEY CLASSIC |
Graf Rink |
| February 22, 2022 | (1) Shrewsbury Colonials at (5) Saint John's Shrewsbury Pioneers
NEWBURYPORT BANK ICE HOCKEY CLASSIC |
Graf Rink |
