| Date & Time | Game | Venue |
|---|---|---|
| December 20, 2021 | (4) Woburn Tanners at (0) Medford Mustangs | LoConte Rink |
| December 22, 2021 | (11) Medford Mustangs at (1) Everett Crimson Tide | Allied Veterans Rink |
| Dec. 26 Postponed | Medford Mustangs at Lynnfield Pioneers
Michael Giodano Tournament |
New England Sports Village |
| Dec. 27 Postponed | Boston Latin or Latin Academy at Medford Mustangs
Postponed: Make-Up TBA -- Michael Giordano Christmas Classic |
Murphy Memorial Rink |
| December 30, 2021 | (0) Medford Mustangs at (2) Bedford Bucs | Edge Sports Center |
| Jan. 8 Postponed | Medford Mustangs at Somerville Highlanders
Postponed: Make-Up TBA |
LoConte Rink |
| January 12, 2022 | (0) Lynn Jets at (11) Medford Mustangs | LoConte Rink |
| January 15, 2022 | (4) Somerville Highlanders at (4) Medford Mustangs | LoConte Rink |
| January 17, 2022 | (0) Medford Mustangs at (5) Winthrop Vikings | Larsen Rink |
| January 19, 2022 | (1) Melrose Red Hawks at (2) Medford Mustangs | LoConte Rink |
| January 22, 2022 | (0) Everett Crimson Tide at (5) Medford Mustangs | LoConte Rink |
| January 22, 2022 | (0) Everett Crimson Tide at (5) Medford Mustangs | LoConte Rink |
| January 25, 2022 | (10) Medford Mustangs at (0) Lynn Jets | Connery Memorial Arena |
| Jan. 29 Postponed | Medford Mustangs at Somerville Highlanders
PPD from 1-29 |
Veterans Memorial Rink |
| January 31, 2022 | (1) Medford Mustangs at (3) Woburn Tanners | John A. Ryan Arena |
| February 02, 2022 | (3) Bedford Bucs at (2) Medford Mustangs | LoConte Rink |
| Feb. 4 Postponed | Medford Mustangs at Somerville Highlanders
Postponed: Make-Up TBA |
Veterans Memorial Rink |
| February 07, 2022 | (5) Lynnfield Pioneers at (0) Medford Mustangs | LoConte Rink |
| February 09, 2022 | (3) Medford Mustangs at (1) Beverly Panthers | Raymond J. Bourque Arena |
| February 14, 2022 | (6) Winthrop Vikings at (1) Medford Mustangs | LoConte Rink |
| February 17, 2022 | (2) Medford Mustangs at (5) Somerville Highlanders | Veterans Memorial Rink |
| February 19, 2022 | (3) North Andover Scarlet Knights at (2) Medford Mustangs | LoConte Rink |
| February 21, 2022 | (6) Framingham Flyers at (0) Medford Mustangs
Cahoon Cup |
Burlington Ice Palace |
| February 23, 2022 | (3) Medford Mustangs at (4) Burlington Red Devils
CAHOON CUP - CONSOLATION |
Burlington Ice Palace |
