| Date & Time | Game | Venue |
|---|---|---|
| December 05, 2021 | North Middlesex Regional at North Middlesex Patriots | New England Sports Center |
| December 11, 2021 | (3) North Middlesex Patriots at (1) Bedford Bucs | Edge Sports Center |
| December 15, 2021 | (1) Leominster Blue Devils at (5) North Middlesex Patriots | Wallace Civic Center |
| December 20, 2021 | (1) North Middlesex Patriots at (4) Nashoba Wolves | New England Sports Center |
| December 27, 2021 | (3) North Middlesex Patriots at (2) Dracut/Tyngsboro Middies | Wallace Civic Center |
| December 29, 2021 | (1) Ashland Clockers at (3) North Middlesex Patriots | Loring Arena |
| January 05, 2022 | (2) North Middlesex Patriots at (2) Westboro Rangers | NorthStar Ice Sports |
| January 12, 2022 | (7) North Middlesex Patriots at (2) Hudson Hawks | New England Sports Center |
| January 15, 2022 | (3) North Middlesex Patriots at (2) Wachusett Mountaineers | Wallace Civic Center |
| January 17, 2022 | (4) North Middlesex Patriots at (2) Groton-Dunstable Crusaders | Wallace Civic Center |
| January 19, 2022 | (2) North Middlesex Patriots at (4) Groton-Dunstable Crusaders | Wallace Civic Center |
| January 22, 2022 | (1) Lexington Minutemen at (2) North Middlesex Patriots | Wallace Civic Center |
| January 26, 2022 | (1) North Middlesex Patriots at (3) Auburn/Millbury Rockets | Horgan Skating Arena |
| Jan. 29 Postponed | Shawsheen Rams at North Middlesex Patriots
ppD from 1-29 |
Wallace Civic Center |
| February 02, 2022 | (2) North Middlesex Patriots at (4) Wachusett Mountaineers | NorthStar Ice Sports |
| February 05, 2022 | (2) Leominster Blue Devils at (3) North Middlesex Patriots | Wallace Civic Center |
| February 08, 2022 | (0) Nashoba Wolves at (3) North Middlesex Patriots | Wallace Civic Center |
| February 12, 2022 | (0) North Middlesex Patriots at (2) Algonquin Titans
Central Mass. Class A Tourament |
NorthStar Ice Sports |
| February 16, 2022 | (3) Groton-Dunstable Crusaders at (2) North Middlesex Patriots
Central MA Class A tournament |
NorthStar Ice Sports |
| February 24, 2022 | (3) Shawsheen Rams at (2) North Middlesex Patriots | Wallace Civic Center |
| March 05, 2022 | (2) North Middlesex Patriots at (3) Nauset Warriors
Boys Division 3 Tournament |
Charles Moore Arena |
