| Date & Time | Game | Venue |
|---|---|---|
| December 10, 2021 | (3) Central Catholic Raiders at (2) Brookline Warriors
Overtime |
Walter Brown Arena |
| December 11, 2021 | (3) Martha's Vineyard Vineyarders at (7) Brookline Warriors | Walter Brown Arena |
| December 15, 2021 | (5) Weymouth Wildcats at (3) Brookline Warriors | Walter Brown Arena |
| December 18, 2021 | (2) Wellesley / Lincoln Sudbury Raiders at (1) Brookline Warriors | Walter Brown Arena |
| December 20, 2021 | (1) Leominster Blue Devils at (4) Brookline Warriors | Walter Brown Arena |
| January 01, 2022 | (0) Stoughton Black Knights at (9) Brookline Warriors | Walter Brown Arena |
| January 02, 2022 | (1) Marblehead Magicians at (2) Brookline Warriors
Hockey Fights Cancer Game: Pink in the Rink |
Walter Brown Arena |
| January 05, 2022 | (2) Brookline Warriors at (0) Newton North/South Tigers | John A. Ryan Arena |
| January 12, 2022 | (6) Natick Red Hawks at (1) Brookline Warriors | Walter Brown Arena |
| January 17, 2022 | (7) Brookline Warriors at (1) Leominster Blue Devils | Wallace Civic Center |
| January 22, 2022 | (0) Brookline Warriors at (2) Braintree Wamps | Zapustas Arena |
| January 24, 2022 | (1) Brookline Warriors at (2) Framingham Flyers | Loring Arena |
| January 26, 2022 | (2) Brookline Warriors at (4) Walpole Timberwolves | Rodman Arena |
| January 31, 2022 | (1) Quincy/North Quincy Red Raiders at (4) Brookline Warriors | Walter Brown Arena |
| February 02, 2022 | (2) Framingham Flyers at (1) Brookline Warriors | Walter Brown Arena |
| February 05, 2022 | (1) Newton North/South Tigers at (1) Brookline Warriors | Walter Brown Arena |
| February 09, 2022 | (2) Brookline Warriors at (6) Wellesley / Lincoln Sudbury Raiders | Boston Sports Institute |
| February 11, 2022 | (0) Brookline Warriors at (4) Natick Red Hawks | Chase Arena |
| February 15, 2022 | (4) Brookline Warriors at (2) Milton Wildcats | Ulin Memorial Rink |
| February 16, 2022 | (4) Needham Rockets at (1) Brookline Warriors
Senior Night |
Walter Brown Arena |
| February 19, 2022 | (2) Brookline Warriors at (1) Nantucket Whalers | Nantucket Ice Skating Rink |
