| Date & Time | Game | Venue |
|---|---|---|
| December 11, 2021 | (7) Pope Francis Cardinals at (0) East/West Bridgewater Vikings | Bridgewater Ice Arena |
| December 19, 2021 | (2) Pope Francis Cardinals at (3) Marblehead Magicians | O'Keefe Athletic Center Salem State |
| Dec. 27 Postponed | East/West Bridgewater Vikings at Pope Francis Cardinals
Postponed: Make-Up TBA |
Amelia Park Rink |
| January 01, 2022 | (1) Pope Francis Cardinals at (2) Algonquin/Hudson Titans | New England Sports Center |
| January 07, 2022 | (2) Pope Francis Cardinals at (3) Longmeadow Lancers | Amelia Park Rink |
| Jan. 8 Postponed | Pope Francis Cardinals at Stoneham/Wilmington Spartans
Postponed: Make-Up TBA |
Stoneham Arena |
| January 13, 2022 | (1) Longmeadow Lancers at (5) Pope Francis Cardinals | Amelia Park Rink |
| January 15, 2022 | (0) Oakmont Spartans at (6) Pope Francis Cardinals
Rescheduled from 12/18/21 |
Fitzpatrick Rink |
| Jan. 16 Postponed | Latin Academy/Fontbonne Dragons at Pope Francis Cardinals
Postponed: Make-Up TBA |
MassMutual Center |
| January 22, 2022 | (1) Auburn Rockets at (3) Pope Francis Cardinals | Smead Arena at Blunt Park |
| January 23, 2022 | (3) Pope Francis Cardinals at (0) Billerica/Chelmsford Indians | Chelmsford Forum |
| January 30, 2022 | (6) Pope Francis Cardinals at (0) Leominster Blue Devils | Wallace Civic Center |
| January 31, 2022 | (0) Pope Francis Cardinals at (6) Acton-Boxboro Revolution
game changed from 12-30 to 1-31-22 |
Nashoba Valley Olympia |
| February 05, 2022 | (0) Woodstock Academy at (3) Pope Francis Cardinals | MassMutual Center |
| February 06, 2022 | (1) Pope Francis Cardinals at (0) Malden Catholic Lancers | Valley Forum II |
| February 11, 2022 | (2) Algonquin/Hudson Titans at (1) Pope Francis Cardinals | Smead Arena at Blunt Park |
| February 12, 2022 | (4) Pope Francis Cardinals at (1) Latin Academy/Fontbonne Dragons | Murphy Memorial Rink |
| February 13, 2022 | (0) Latin Academy/Fontbonne Dragons at (6) Pope Francis Cardinals | Smead Arena at Blunt Park |
| February 19, 2022 | (0) Pope Francis Cardinals at (3) St. Mary's Lynn Spartans | Connery Memorial Arena |
| February 21, 2022 | (4) Norwell at (2) Pope Francis Cardinals
Newburyport Bank Classic Tournament |
Graf Rink |
| February 23, 2022 | (1) Pope Francis Cardinals at (1) Newburyport Clippers
Newburyport Bank Classic Tournament |
Graf Rink |
| February 24, 2022 | (5) Pope Francis Cardinals at (2) Stoneham/Wilmington Spartans | Stoneham Arena |
| March 04, 2022 | (4) Quincy/North Quincy Red Raiders at (5) Pope Francis Cardinals
Girls Division 1 Tournament |
Smead Arena at Blunt Park |
| March 08, 2022 | (1) Pope Francis Cardinals at (2) Notre Dame Academy (Hingham) Cougars
Girls Division 1 Tournament |
Rockland Arena |
